PROTECTION OF MICE AGAINST LETHAL COXSACKIEVIRUS B3 INFECTION BY USING DNA IMMUNIZATION

Authors
HENKE A WAGNER E WHITTON JL ZELL R STELZNER A
Citation
A. Henke et al., PROTECTION OF MICE AGAINST LETHAL COXSACKIEVIRUS B3 INFECTION BY USING DNA IMMUNIZATION, Journal of virology, 72(10), 1998, pp. 8327-8331
Citations number
16
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
72
Issue
10
Year of publication
1998
Pages
8327 - 8331
Database
ISI
SICI code
0022-538X(1998)72:10<8327:POMALC>2.0.ZU;2-J
Abstract
Vaccination with DNA and recombinant vaccinia viruses (rec.VV) has bee n studied with the coxsackievirus B3 (CVB3) model system. Plasmids enc oding all structural proteins of CVB3, when injected intramuscularly, induced only low levels of virus-specific antibodies. However, DNA vac cination with the major structural protein VP1 protected 72.2% of mice from lethal challenge, whereas VP1 expressed by rec.VV was much less efficient.