This chapter aims to provide a current review of the use of Doppler ul
trasound in the management of multiple pregnancies. OVID and Medline s
earches were undertaken. Randomized controlled trials, where available
, were assessed by the Cochrane Review Manager (RevMan-version 3.0). T
he specific multiple pregnancy problems of fetal growth restriction (F
GR), twin reversed arterial perfusion sequence and twin-twin transfusi
on syndrome (TTTS) were also reviewed. Historically, controlled and ra
ndomized controlled trials show a promising reduction in perinatal mor
tality in twin pregnancies where Doppler ultrasound is used. However,
the numbers are small and Further trials are recommended. In those twi
n pregnancies in which there is FCR as a result of placental dysfuncti
on, Doppler ultrasonography will show intertwin discordancy. In those
twin pairs where development is complicated by TTTS, there is often di
scordant fetal size, with concordant fetal Doppler results. Thus Doppl
er ultrasound appears to be useful in the management of twin pregnanci
es and in delineating those complicated by FGR and TTTS.