ENANTIOMERIC SEPARATION OF BETA-AMINO ALCOHOLS BY CAPILLARY-ELECTROPHORESIS USING DM-BETA-CD AS CHIRAL SELECTOR

Enantiomeric separations of several beta-amino alcohol drugs, i.e., ph enylephrine, epinephrine, norepinephrine, synephrine, and chlorprenali ne were performed by capillary electrophoresis using DM-beta-CD as a c hiral selector. Five test solutes were baseline resolved in six minute s. The effects of DM-beta-CD concentration, pH value, ionic strength o f the buffer, and the type of beta-CDs on resolution were investigated . The results indicated that DM-beta-CD is suitable for enantiomeric s eparation of beta-amino alcohols containing a phenyl group on the chir al atom. Enantiorecognition mechanisms for test solutes are also discu ssed.