AN EFFICIENT HIGH-SPEED SYNTHETIC ROUTE TO AMINO-SUBSTITUTED THIAZOLIDINONE LIBRARIES

Authors
MUNSON MC COOK AW JOSEY JA RAO C
Citation
Mc. Munson et al., AN EFFICIENT HIGH-SPEED SYNTHETIC ROUTE TO AMINO-SUBSTITUTED THIAZOLIDINONE LIBRARIES, Tetrahedron letters, 39(40), 1998, pp. 7223-7226
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
40
Year of publication
1998
Pages
7223 - 7226
Database
ISI
SICI code
0040-4039(1998)39:40<7223:AEHSRT>2.0.ZU;2-H
Abstract
An efficient solid-phase synthesis of amino-substituted thiazolidinone s using an acid-labile carbamate linkage is reported. In this approach , excess unprotected symmetrical diamine is incorporated directly onto a carbonylimidazole activated Wang support followed by imine formatio n on the remaining free primary amine, cyclization and amide bond expa nsion. (C) 1998 Elsevier Science Ltd. All rights reserved.