DESIGN OF NEW ANTICANCER DRUGS - I - EASY HETARYNIC ACCESS TO DIHYDRODIPYRIDOPYAZINES, A NEW FAMILY OF ANTITUMOR AGENTS

Authors
RODRIGUEZ I KUEHMCAUBERE C VINTERPASQUIER K RENARD P PFEIFFER B CAUBERE P
Citation
I. Rodriguez et al., DESIGN OF NEW ANTICANCER DRUGS - I - EASY HETARYNIC ACCESS TO DIHYDRODIPYRIDOPYAZINES, A NEW FAMILY OF ANTITUMOR AGENTS, Tetrahedron letters, 39(40), 1998, pp. 7283-7286
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
40
Year of publication
1998
Pages
7283 - 7286
Database
ISI
SICI code
0040-4039(1998)39:40<7283:DONAD->2.0.ZU;2-7
Abstract
Unprecedented dihydrodipyridopyrazines were easily obtained by hetaryn ic dimerization of 2-alkylamino-3-bromopyridines in the presence of th e complex base NaNH2-tBuONa. A few chemical properties of these new he terocycles are reported, as well as their antitumoral activity. (C) 19 98 Published by Elsevier Science Ltd. All rights reserved.