SYNTHESIS OF PEPTIDE ALDEHYDES ON SOLID SUPPORT USING OZONOLYSIS

Authors
PARIS M HEITZ A GUERLAVAIS V CRISTAU M FEHRENTZ JA MARTINEZ J
Citation
M. Paris et al., SYNTHESIS OF PEPTIDE ALDEHYDES ON SOLID SUPPORT USING OZONOLYSIS, Tetrahedron letters, 39(40), 1998, pp. 7287-7290
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
40
Year of publication
1998
Pages
7287 - 7290
Database
ISI
SICI code
0040-4039(1998)39:40<7287:SOPAOS>2.0.ZU;2-#
Abstract
A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected alpha-amino aldehyde with MBH A-supported Wittig ou Wittig-Homer reagent yielded resin-linked alpha- beta-unsaturated delta-amino derivative. After elongation of the pepti de chain, ozonolysis produced fairly pure C-terminal peptide aldehydes in good yield. (C) 1998 Elsevier Science Ltd. All rights reserved.