ACTIVATION OF TETRABUTYLAMMONIUM HYDROGEN DIFLUORIDE WITH PYRIDINE - A MILD AND EFFICIENT PROCEDURE FOR NUCLEOPHILIC FLUORINATION

Authors
MOUGHAMIR K ATMANI A MESTDAGH H ROLANDO C FRANCESCH C
Citation
K. Moughamir et al., ACTIVATION OF TETRABUTYLAMMONIUM HYDROGEN DIFLUORIDE WITH PYRIDINE - A MILD AND EFFICIENT PROCEDURE FOR NUCLEOPHILIC FLUORINATION, Tetrahedron letters, 39(40), 1998, pp. 7305-7306
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
40
Year of publication
1998
Pages
7305 - 7306
Database
ISI
SICI code
0040-4039(1998)39:40<7305:AOTHDW>2.0.ZU;2-G
Abstract
The nucleophilic fluorination of alkyl iodides, bromides and tosylates and of alpha-bromo- or alpha-chloroketones is smoothly effected by te trabutylammonium hydrogen difluoride in the presence of pyridine, in d ioxane or THF, with good or satisfying substitution-to-elimination rat io. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.