Bh. Xie et al., THE FIRST ASYMMETRIC CARBONYLATION OF 1-(6'-METHOXY-2'-NAPHTHYL)ETHANOL TO THE METHYL-ESTER OF (S)-NAPROXEN, Tetrahedron letters, 39(40), 1998, pp. 7365-7368
1-(6'-Methoxy-2'-naphthyl)ethanol is asymmetrically carbonylated to th
e methyl ester of (S)-naproxen in a PdCl2-CuCl2-DDPPI (DDPPI: o-2,5-di
deoxy-2,5-bis(diphenylphosphino)-L-iditol) catalytic system with a che
mical yield of 90% and an optical yield of 81% e.e.. The reaction was
carried out in ethyl methyl ketone under 100 degrees C and 8 MPa of CO
for 24-48h. (C) 1998 Elsevier Science Ltd. All rights reserved.