SOLID-PHASE SYNTHESIS OF 3,5-DISUBSTITUTED 1,3-OXAZOLIDIN-2-ONES BY AN ACTIVATION CYCLO-ELIMINATION PROCESS/

Authors
TENHOLTE P THIJS L ZWANENBURG B
Citation
P. Tenholte et al., SOLID-PHASE SYNTHESIS OF 3,5-DISUBSTITUTED 1,3-OXAZOLIDIN-2-ONES BY AN ACTIVATION CYCLO-ELIMINATION PROCESS/, Tetrahedron letters, 39(40), 1998, pp. 7407-7410
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
40
Year of publication
1998
Pages
7407 - 7410
Database
ISI
SICI code
0040-4039(1998)39:40<7407:SSO31B>2.0.ZU;2-V
Abstract
Polymer-supported sulfonyl chloride is used in the solid-phase synthes is of disubstituted 1,3-oxazolidin-2-ones. The target compounds were p repared by attaching 1,2-diols to the solid support, followed by react ion with p-toluenesulfonyl isocyanate and subsequent cycle-elimination with concurrent detachment from the resin. Oxazolidinones of high ena ntiopurity can be prepared with this method by employing enantiopure 1 ,2-diols. (C) 1998 Elsevier Science Ltd. All rights reserved.