TRANSDERMAL ALNIDITAN DELIVERY BY SKIN ELECTROPORATION

The aim of this study was to evaluate the transdermal permeation of al niditan by electroporation and to compare with iontophoretic delivery. The influence of the electrical parameters of electroporation was inv estigated in vitro using a factorial design study. The transdermal flu x of alniditan was enhanced by two orders of magnitude by application of high voltage electrical pulses. The electrical parameters of electr oporation - i.e. the voltage, the duration and the number of pulses al lowed a control of drug permeation. Both transport during and after pu lsing were shown to be important for alniditan transdermal delivery by electroporation. Electroporation was found more efficient in promotin g alniditan permeation than an iontophoresis transferring the same amo unt of charges. (C) 1998 Elsevier Science B.V. All rights reserved.