PATHOLOGICAL-CHANGES, MECHANISMS AND DIAGNOSIS IN RENAL BONE-DISEASE

Objective To investigate the incidence rate, pathologic changes, mecha nisms and diagnostic methods in renal bone disease. Methods The blood levels of carboxyterminal parpthyriod hormone (C-PTH), 1,25(OH)(2)D-3, calcium and phosphate, aluminum in serum and bone tissue were measure d. The bone biopsy and bone scan with (99m) technetium methylene dipho sphonate ((99m) TC-MDP) were performed in 51 uremic patients. Results One hundred per cent of the patients had varying degree of pathologic changes in bone, in which 50.9% of the patients presented high-turnove r bone disease, 7.8% of the patients presented lowe-turnover bone dise ase and 41.8% of the patients had mixed-type bone disease. The levels of serum C-PTH were predominently high in high-turnover bone disease w hile the levels of serum 1,25(OH)(2)D-3 were significantly decreased i n low-tumover bone disease. There was a high positive rate for the dia gnosis of renal bone disease by bone scan with (99m) TC-MDP. Conclusio ns The examination of bone pathology is the most valuable method for t he diagnosis of renal bone disease. Bone scan with (99m) TC-MDP has re ference value when clinical conditions do not allow to make bone biops y.