We report the case of a 79-year-old man who had onset of fatigue, myal
gia, and pleuritic chest pain 3 months after initiation of therapy wit
h simvastatin. He had signs of pleuropericarditis due to simvastatin-i
nduced lupus erythematosus. This should alert clinicians to this possi
ble adverse effect of simvastatin and other statins.