E. Chavez et al., HYPOTHYROIDISM RENDERS LIVER-MITOCHONDRIA RESISTANT TO THE OPENING OFMEMBRANE-PERMEABILITY TRANSITION PORE, Biochimica et biophysica acta. Molecular basis of disease, 1407(3), 1998, pp. 243-248
Membrane permeability was examined in liver mitochondria isolated from
hypothyroid rats. It was found that such a thyroid status provides su
bstantial protection from membrane leakiness as induced by Ca2+ loadin
g. Thus, these mitochondria are less prone to undergoing permeability
transition than mitochondria from euthyroid rats. The above conclusion
was reached on the basis of the following two facts: (1) hypothyroid
mitochondria are not strictly dependent on the addition of ADP to reta
in high matrix Ca2+ concentrations, and (2) carboxyatractyloside, anti
mycin A or carbonyl cyanide-m-chlorophenyl hydrazone failed to promote
Ca2+ afflux. We discuss the possible relevance of the low content of
membrane cardiolipin as well as the low expression of the adenine nucl
eotide translocase as responsible for the resistance to membrane damag
e. (C) 1998 Elsevier Science B.V. All rights reserved.