Bh. Sen et al., MORPHOLOGIC EFFECTS ON L929 FIBROBLASTS OF TITANIUM TETRAFLUORIDE APPLICATION, Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 86(3), 1998, pp. 341-346
Citations number
30
Categorie Soggetti
Pathology,Surgery,"Dentistry,Oral Surgery & Medicine
Objective. The aim of this study was to investigate the effect of tita
nium tetrafluoride solution on L929 fibroblasts by scanning electron m
icroscopy. Titanium tetrafluoride was then compared with sodium fluori
de and acidulated phosphate fluoride. Study design. Cells were treated
with fluoride solutions for 1 minute either directly, through a filte
r membrane with a pore size of 0.4-mu m, or indirectly, through dentin
disks; they were then investigated at an electron microscopic level.
Results. Fluoride application on smeared dentin disks showed fewer cyt
otoxic effects on fibroblasts than application on nonsmeared dentin di
sks. Acidulated phosphate fluoride and titanium tetrafluoride appeared
to be more cytotoxic than sodium fluoride. Because all fluoride solut
ions used in this study contained the same fluoride concentration, pH
was considered to be the main factor causing the higher toxicity. Conc
lusion. Because these solutions demonstrated toxicity in vitro, they m
ust be further evaluated under in vivo conditions to ascertain their c
linical safety.