HORSERADISH PEROXIDASE-CATALYZED ENANTIOSELECTIVE REDUCTION OF RACEMIC HYDROPEROXY HOMOALLYLIC ALCOHOLS - A NOVEL ENZYMATIC METHOD FOR THE PREPARATION OF OPTICALLY-ACTIVE, UNSATURATED DIOLS AND HYDROPEROXY ALCOHOLS

Authors
ADAM W LAZARUS M HOCH U KORB MN SAHAMOLLER CR SCHREIER P
Citation
W. Adam et al., HORSERADISH PEROXIDASE-CATALYZED ENANTIOSELECTIVE REDUCTION OF RACEMIC HYDROPEROXY HOMOALLYLIC ALCOHOLS - A NOVEL ENZYMATIC METHOD FOR THE PREPARATION OF OPTICALLY-ACTIVE, UNSATURATED DIOLS AND HYDROPEROXY ALCOHOLS, Journal of organic chemistry, 63(18), 1998, pp. 6123-6127
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
63
Issue
18
Year of publication
1998
Pages
6123 - 6127
Database
ISI
SICI code
0022-3263(1998)63:18<6123:HPEROR>2.0.ZU;2-3
Abstract
The kinetic resolution of chiral diastereomeric hydroperoxy homoallyli c alcohols 1 by horseradish peroxidase-catalyzed asymmetric reduction affords the optically active (R,R) or (R,S) allylic diols 2 and (S,S) or (SP) hydroperoxy homoallylic alcohols 1 in high enantiomeric excess (up to 99%).