CEREBRAL MANIFESTATION OF WILSONS-DISEASE SUCCESSFULLY TREATED WITH LIVER-TRANSPLANTATION

The main indication for orthotopic liver transplantation (OLTx) in Wil son's disease (WD) is severe hepatic decompensation. Our 15-year-old p atient is the second case to date in whom OLTx was performed because o f neurologic manifestations resulting from WD. His initial condition i nvolving recurrent headaches, tremor, and athetoid hand movements prog ressively deteriorated during therapy with D-penicillamine, zinc sulfa te, and trientine until he was severely dysarthric, unable to walk, an d bedridden. After OLTx, his neurologic condition became almost normal .