FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS WITH WIDESPREAD VACUOLATION AND HYALINE INCLUSIONS

This report presents a familial amyotrophic lateral sclerosis (FALS) p atient with widespread vacuoles and hyaline inclusions strongly immuno stained with the anti-superoxide dismutase (SOD1) antibody. The overal l pathologic similarity between our non-SOD1-linked FALS patient and t ransgenic mice expressing a mutated human SOD1 gene suggests that comm on pathogenetic mechanisms other than an SOD1 mutation exist in the de velopment of these diseases.