GABAPENTIN IN ORTHOSTATIC TREMOR - RESULTS OF A DOUBLE-BLIND CROSSOVER WITH PLACEBO IN 4 PATIENTS

We treated four patients affected by orthostatic tremor (OT) with gaba pentin in increasing doses (300 to 2,400 mg/d). OT was evaluated with patients' self-monitoring scales, tremor rating scales, electromyograp hy (EMG) showing the 14- to 18-Hz frequencies, and EMG frequency analy sis. All patients had transitory responses to clonazepam. Gabapentin i nduced disappearance of OT in three patients and consistent reduction in one. Crossover to placebo induced reappearance of tremor.