COUMARIN 1,4-DIHYDROPYRIDINE DERIVATIVES

Authors
VALENTI P RAMPA A BUDRIESI R BISI A CHIARINI A
Citation
P. Valenti et al., COUMARIN 1,4-DIHYDROPYRIDINE DERIVATIVES, Bioorganic & medicinal chemistry, 6(6), 1998, pp. 803-810
Citations number
30
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
6
Year of publication
1998
Pages
803 - 810
Database
ISI
SICI code
0968-0896(1998)6:6<803:C1D>2.0.ZU;2-E
Abstract
A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-positi on was synthesized. The compounds were evaluated for inotropic, chrono tropic and calcium antagonist activities. The replacement of the o-nit rophenyl moiety of nifedipine with a coumarin or phenylcoumarin system is accompained by a decrease of the activity on myocardial and vascul ar parameters, but the synthesized compounds showed selective inhibiti ng effects on cardiac contractility and frequency. (C) 1998 Elsevier S cience Ltd. All rights reserved.