MECHANISM OF BIOCHEMICAL-ACTION OF SUBSTITUTED 4-METHYLBENZOPYRAN-2-ONES - PART I - DIOXYGENATED 4-METHYL COUMARINS AS SUPERB ANTIOXIDANT AND RADICAL SCAVENGING AGENTS

Authors
RAJ HG PARMAR VS JAIN SC GOEL S",POONAM,HIMANSHU,"MALHOTRA S SINGH A OLSEN CE WENGEL J
Citation
Hg. Raj et al., MECHANISM OF BIOCHEMICAL-ACTION OF SUBSTITUTED 4-METHYLBENZOPYRAN-2-ONES - PART I - DIOXYGENATED 4-METHYL COUMARINS AS SUPERB ANTIOXIDANT AND RADICAL SCAVENGING AGENTS, Bioorganic & medicinal chemistry, 6(6), 1998, pp. 833-839
Citations number
29
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
6
Year of publication
1998
Pages
833 - 839
Database
ISI
SICI code
0968-0896(1998)6:6<833:MOBOS4>2.0.ZU;2-I
Abstract
Twenty-three 4-methylcoumarins bearing different functionalities have been examined for the first time for their effect on NADPH-catalysed l iver-microsomal lipid peroxidation with a view to establish structure- activity relationship. Dihydroxy- and diacetoxy-4-methylcoumarins prod uced dramatic inhibition of lipid peroxidation. 7,8-Diacetoxy-4-methyl coumarin and 7,8-dihydroxy-4-methylcoumarin were found to possess supe rb antioxidant and radical scavenging activities. (C) 1998 Elsevier Sc ience Ltd. All rights reserved.