GENE STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN P2X(7) RECEPTOR

Authors
BUELL GN TALABOT F GOS A LORENZ J LAI E MORRIS MA ANTONARAKIS SE
Citation
Gn. Buell et al., GENE STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN P2X(7) RECEPTOR, Receptors & channels, 5(6), 1998, pp. 347
Citations number
27
Categorie Soggetti
Biology,"Cell Biology
Journal title
Receptors & channels → ACNP
ISSN journal
10606823
Volume
5
Issue
6
Year of publication
1998
Database
ISI
SICI code
1060-6823(1998)5:6<347:GSACLO>2.0.ZU;2-J
Abstract
The genomic organization for the human P2X(7) receptor gene was determ ined to comprise 13 exons. Alignment of the exon-intron junctions with those for the rat P2X(2) gene demonstrated a precise conservation of the boundaries for the first 10 introns. The human P2X(7) receptor gen e was localized by in situ hybridization to chromosome 12q24. Radiatio n hybrid mapping indicated that this is within 130 kb of the gene for the homologous P2X(4) receptor.