There are structural and functional changes which take place in the ki
dney with age. These changes have an impact on patient management, par
ticularly with respect to drug therapy. It is unlikely that glomerulon
ephritis is less common in the elderly, and any apparent difference wi
th respect to younger patients most likely reflects clinical practice
rather than any inherent difference in the aged kidney. Tubulointersti
tial nephritis may be more common and is most likely linked to drug th
erapy. The management of end-stage renal failure in the elderly should
not be significantly different from that in younger patients and shou
ld be based on the capacity for rehabilitation rather than any arbitra
ry age.