BIOACTIVE NAPHTHOQUINONE DERIVATIVES FROM DIOSPYROS-MARITIMA BLUME

From the fresh fruits of Diospyros maritima BLUME (Ebenaceae) three ne w naphthoquinones, 3-bromoplumbagin (1), ethylidene-6,6'-biplumbagin ( 2), and 3-(2-hydroxyethyl)plumbagin (3), were isolated, in addition to six known naphthoquinones, 3-chloroplumbagin (4), 3-methylplumbagin ( 5), plumbagin (6), droserone (7), elliptinone (8), and maritinone (9). The structures of the new compounds were established by chemical acid spectroscopic means. The 21 compounds isolated from this plant were e xamined for ichthyotoxic activity, germination inhibitory activity, an d antifungal activity. The naphthoquinone derivatives from the fruits of Diospyros maritima showed a variety of biological activities, espec ially plumbagin (6), which showed strong activity in these three bioas says.