INVESTIGATION OF THE MICROPRECIPITATION OF FOLIC-ACID FROM SLIGHTLY ACIDIC INJECTION SOLUTIONS USING DYNAMIC LIGHT-SCATTERING

Authors
KEKI S SIPOS T DEAK G MEZEY G ZSUGA M
Citation
S. Keki et al., INVESTIGATION OF THE MICROPRECIPITATION OF FOLIC-ACID FROM SLIGHTLY ACIDIC INJECTION SOLUTIONS USING DYNAMIC LIGHT-SCATTERING, Chemical and Pharmaceutical Bulletin, 46(8), 1998, pp. 1333-1334
Citations number
7
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
8
Year of publication
1998
Pages
1333 - 1334
Database
ISI
SICI code
0009-2363(1998)46:8<1333:IOTMOF>2.0.ZU;2-X
Abstract
Microprecipitation of folic acid was monitored by the dynamic light sc attering (DLS) method. The pH was changed by CO2 absorption and additi on of HCl. The folic acid solutions were examined over the pH range 8. 5-4.0. Over the pH range 5.4-6.0, microprecipitation was observed and at pH less than or equal to 5.2 crude precipitation of folic acid occu rred. The dependence of the effective diameter on the pH over the pH r ange 5.4-6.0 is also reported.