KOTALANOL, A POTENT ALPHA-GLUCOSIDASE INHIBITOR WITH THIOSUGAR SULFONIUM SULFATE STRUCTURE, FROM ANTIDIABETIC AYURVEDIC MEDICINE SALACIA-RETICULATA

Authors
YOSHIKAWA M MURAKAMI T YASHIRO K MATSUDA H
Citation
M. Yoshikawa et al., KOTALANOL, A POTENT ALPHA-GLUCOSIDASE INHIBITOR WITH THIOSUGAR SULFONIUM SULFATE STRUCTURE, FROM ANTIDIABETIC AYURVEDIC MEDICINE SALACIA-RETICULATA, Chemical and Pharmaceutical Bulletin, 46(8), 1998, pp. 1339-1340
Citations number
17
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
8
Year of publication
1998
Pages
1339 - 1340
Database
ISI
SICI code
0009-2363(1998)46:8<1339:KAPAIW>2.0.ZU;2-P
Abstract
A potent natural alpha-glucosidase inhibitor called kotalanol has been isolated from an antidiabetic traditional Ayurvedic medicine, the roo ts and stems of Salacia reticulata WIGHT, through bioassay-guided sepa ration. The structure of kotalanol was elucidated on the basis of chem ical and physicochemical evidence to be the inner salt comprised of 1- deoxyheptosyl-3-sulfate anion and 1-deoxy-4-thio-D-arabinofuranosyl su lfonium cation, Kotalanol was found to show more potent inhibitory act ivity against sucrase than salacinol and acarbose.