AN EASY AND FAST WAY TO DETERMINE THE ENANTIOMERIC PURITY OF SUBSTITUTED CYCLANONES

Authors
ALEXAKIS A FRUTOS JC MANGENEY P
Citation
A. Alexakis et al., AN EASY AND FAST WAY TO DETERMINE THE ENANTIOMERIC PURITY OF SUBSTITUTED CYCLANONES, Tetrahedron : asymmetry, 4(12), 1993, pp. 2431-2434
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
4
Issue
12
Year of publication
1993
Pages
2431 - 2434
Database
ISI
SICI code
0957-4166(1993)4:12<2431:AEAFWT>2.0.ZU;2-0
Abstract
The determination of the enantiomeric purity of 2 or 3-substituted cyc lanones, particularly cyclohexanones, is conveniently achieved by deri vatisation into cyclic aminals with commercially available (R, R)-1,2- diphenylethylenediamine. The derivatisation procedure is directly done into the NMR tube, instantaneously, and C-13 NMR allows an accurate m easure of the ee.