RUTHENIUM (II)-SULFONATED BINAP - A NOVEL WATER-SOLUBLE ASYMMETRIC HYDROGENATION CATALYST

Authors
WAN KT DAVIS ME
Citation
Kt. Wan et Me. Davis, RUTHENIUM (II)-SULFONATED BINAP - A NOVEL WATER-SOLUBLE ASYMMETRIC HYDROGENATION CATALYST, Tetrahedron : asymmetry, 4(12), 1993, pp. 2461-2468
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
4
Issue
12
Year of publication
1993
Pages
2461 - 2468
Database
ISI
SICI code
0957-4166(1993)4:12<2461:R(B-AN>2.0.ZU;2-W
Abstract
Ruthenium (II)-sulfonated-BINAP has been synthesized and this novel wa ter-soluble complex is shown to be an excellent asymmetric hydrogenati on catalyst for 2-acylamino acid precursors and methylenesuccinic acid in both methanolic as well as in neat water solvent systems. Enantiom eric excesses approaching 90% have been obtained in aqueous and methan olic solvents. Effects of solvent, pressure and the addition of organi c base on enantioselectivity are described.