MICROBIAL OXIDATION OF 2-BROMOSTYRENE BY PSEUDOMONAS-PUTIDA 39 D - ISOLATION AND IDENTIFICATION OF METABOLITES/

Authors
KONIGSBERGER K HUDLICKY T
Citation
K. Konigsberger et T. Hudlicky, MICROBIAL OXIDATION OF 2-BROMOSTYRENE BY PSEUDOMONAS-PUTIDA 39 D - ISOLATION AND IDENTIFICATION OF METABOLITES/, Tetrahedron : asymmetry, 4(12), 1993, pp. 2469-2474
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
4
Issue
12
Year of publication
1993
Pages
2469 - 2474
Database
ISI
SICI code
0957-4166(1993)4:12<2469:MOO2BP>2.0.ZU;2-#
Abstract
2-Bromostyrene was subjected to microbial oxidation by two microorgani sms. Oxidation by Pseudomonas putida 39/D yielded a mixture of ring di hydroxylated (1S,2R)-4-bromo-3-ethenylcyclohexa-3,5-diene-1,2-d (4a) ( optical purity o.p.>92%) and side chain dihydroxylated (1R)-1-(2-bromo phenyl)ethan-1,2-diol (5a) (o.p. 91%) (ratio 4a:5a = 1:4) in a yield o f 100 mg/L. Pseudomonas sp. NCIB 9816-11 afforded only 5a.