MINIATURIZATION FOR DRUG DISCOVERY APPLICATIONS

When combinatorial chemistry emerged in the early nineties, miniaturiz ation was a prerequisite for many breakthrough approaches. A wave of s cale-up development ensued, driven by the need to interface this techn ology with classical medicinal chemistry. A renaissance of the microsc opic perspective is now taking place, motivated by the implementation of increased throughput screening and the application of concepts and hardware from the diagnostics and genomics sectors. The author describ es the different approaches of wet-chip technology with reference to t he generation of molecular diversity.