THE UNDERLYING STRUCTURE OF THE SUBTELOMERIC REGION DETECTED BY MICROPHOTOMETRICAL SCANNING AND CHROMOSOME GRAPHIC IMAGE-ANALYSIS

Authors
DRETS ME MENDIZABAL M
Citation
Me. Drets et M. Mendizabal, THE UNDERLYING STRUCTURE OF THE SUBTELOMERIC REGION DETECTED BY MICROPHOTOMETRICAL SCANNING AND CHROMOSOME GRAPHIC IMAGE-ANALYSIS, Mutation research. Fundamental and molecular mechanisms of mutagenesis, 404(1-2), 1998, pp. 13-16
Citations number
16
Categorie Soggetti
Genetics & Heredity",Toxicology,"Biothechnology & Applied Migrobiology
Journal title
Mutation research. Fundamental and molecular mechanisms of mutagenesis
ISSN journal
13861964 → ACNP
Volume
404
Issue
1-2
Year of publication
1998
Pages
13 - 16
Database
ISI
SICI code
1386-1964(1998)404:1-2<13:TUSOTS>2.0.ZU;2-S
Abstract
Previous research showed that the microphotometrical scanning of T-ban ded subtelomeric regions reveals the presence of specific patterns of the Giemsa stain density distributions as detected in chromosomes of n ormal human lymphocytes and CHO cells, Analyses with this method of th e T-banded subtelomeric segments of CHO endoreduplicated chromosomes c onfirmed that these density patterns replicate in a similar way in sis ter chromosomes, Besides, the specific removal of portions of the subt elomeric segments appearing as tiny holes located where these density patterns are found suggested that both phenomena are related. The poss ible connection of these findings to the molecular structure of the su btelomeric region is briefly discussed. (C) 1998 Elsevier Science B.V. All rights reserved.