A 2ND MIDDLE-EASTERN KINDRED WITH AUTOSOMAL RECESSIVE NON-SYNDROMIC HEARING-LOSS SEGREGATES DFNB9

A second kindred has been identified which supports the previously rep orted location of DFNB9. Linkage has been established to markers close ly linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers w ere placed on this genetic map using a likelihood ratio criterion of 1 000:1. This map suggests that the region for DFNB9 is less than 1.08 c M, 95% confidence interval (0-2.59 cM).