RELATION BETWEEN URINARY CYTOLOGY ABNORMALITIES AND CYCLOSPORINE-A THERAPY IN BONE-MARROW TRANSPLANT RECIPIENTS

The aim of the study was to determine the relationship, if any, betwee n abnormalities in urinary cytology and the administration of cyclospo rine A in bone marrow transplant recipients. Specific attention was gi ven to the presence of tubular cells with round inclusions (TCRI). Two bone marrow transplant recipient groups were studied: one with alloge neic bone marrow transplantation (BMT) (20 patients) who were treated with cyclosporine A, and the other with autologous BMT (12 patients) w ho did not receive cyclosporine A. Urinary cytology showed TCRI in 41. 66% of the patients after autologous BMT and in 80% of the patients af ter allogeneic BMT. In the group of patients treated with allogeneic B MT, the occurrence of TCRI was associated with a high incidence of gly cosuria and was followed by an increase in the blood level of cyclospo rine A, an increase in the serum creatinine concentration and a decrea se in the creatinine clearance. These results demonstrated that TCRI, although related to, were not found to be exclusively specific to the administration of cyclosprine A.