MUTAGENICITY OF THE HUMAN BLADDER CARCINOGEN 4-AMINOBIPHENYL TO THE BLADDER OF MUTA(TM)MOUSE TRANSGENIC MICE

The human carcinogen 4-aminobiphenyl (4AB) was evaluated in the Muta(T M)Mouse transgenic mouse mutation assay. A single oral dose of 75 mg/k g induced 6.9-, 1.8- and 2.2-fold increases in the mutation frequency (MF) in the bladder, liver and bone marrow, respectively. Ten daily or al doses of 10 mg/kg 4AB increased the MF in the bladder, Liver and bo ne marrow by 13.7-, 4.8- 2.4-fold the control value, respectively. The repeat dosing protocol was therefore more sensitive than the single d ose protocol. Assessment of DNA samples prepared from pooled liver hom ogenates clearly indicated the increase in MF observed in the individu al liver samples obtained from both groups of 4AB-treated mice. (C) 19 98 Elsevier Science B.V. All rights reserved.