Rationale and Objectives. This study was performed to determine physic
al characteristics of areas on chest radiographs that are suspicious b
ut not definitive for the presence of a pulmonary nodule and the chara
cteristics of areas that contain an obvious nodule. Materials and Meth
ods. Two groups of patients were identified: those who had an area at
plain radiography that was suspicious for a pulmonary nodule and under
went fluoroscopy for further evaluation (138 patients, 142 areas)and t
hose who had an obvious nodule at plain radiography who underwent comp
uted tomography for further evaluation (72 patients, 97 areas). The me
asured characteristics of the region of interest included size, circul
arity, compactness, contrast, and location. Results. A comparison of t
he data show that while there was some difference between these groups
of patients with regard to location of the nodules, there were essent
ially no differences with regard to size, circularity, corn compactnes
s, and contrast of the regions of interest. Conclusion. Size, circular
ity, compactness, contrast, and location are not sufficient to disting
uish pulmonary nodules from other suspicious regions on the chest radi
ograph.