SYNTHESIS AND CHARACTERIZATION OF ALPHA-PHOSPHORYLATED KETONES - MODELS FOR THE MOLYBDOPTERIN PRECURSOR

Authors
VANHOUTEN KA BOGGS CV PILATO RS
Citation
Ka. Vanhouten et al., SYNTHESIS AND CHARACTERIZATION OF ALPHA-PHOSPHORYLATED KETONES - MODELS FOR THE MOLYBDOPTERIN PRECURSOR, Tetrahedron, 54(37), 1998, pp. 10973-10986
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
37
Year of publication
1998
Pages
10973 - 10986
Database
ISI
SICI code
0040-4020(1998)54:37<10973:SACOAK>2.0.ZU;2-H
Abstract
Synthesis of pyridyl substituted a-keto six memebered cyclic phosphate s is reported. These compounds are structurally similar to the precurs or of molybdopterin (MPT), an important biological cofactor. We demons trate that these a-phosphorylated ketones can undergo the fundamental transformation required for MPT synthesis. (C) 1998 Elsevier Science L td. All rights reserved.