GATHERING STYX - PHOSPHATASE LIKE FORM PREDICTS FUNCTIONS FOR UNIQUE PROTEIN-INTERACTION DOMAINS

The effects of tyrosine phosphorylation are manifested and regulated t hrough protein domains that bind to specific phosphotyrosine motifs. S TYX is a unique modular domain found within proteins implicated in med iating the effects of tyrosine phosphorylation in vivo. Individual STY X domains are not catalytically active; however, they resemble protein tyrosine phosphatase (PTP) domains and, like PTPs, contain core seque nces that recognize phosphorylated substrates. Thus, the STYX domain a dds to the repertoire of modular domains that can mediate intracellula r signaling in response to protein phosphorylation.