ANIMAL ELECTRICITY AND THE BIRTH OF ELECTROPHYSIOLOGY - THE LEGACY OFGALVANI,LUIGI

Preceded by a companion paper on Galvani's life, this article is writt en on the occasion of the bicentenary of the death of Luigi Galvani, F rom his studies on the effects of electricity on frogs, the scientist of Bologna derived the hypothesis that animal tissues are endowed with an intrinsic electricity that is involved in fundamental physiologica l processes such as nerve conduction and muscle contraction, Galvani's work swept away from life sciences mysterious fluids and elusive enti ties like ''animal spirits'' and led to the foundation of a new scienc e, electrophysiology. Two centuries of research work have demonstrated how insightful was Galvani's conception of animal electricity. Nevert heless, the scholar of Bologna is still largely misrepresented in the history of science, because the importance of his researches seems to be limited to the fact that they opened the paths to the studies of th e physicist Alessandro Volta, which culminated in 1800 with the invent ion of the electric battery. Volta strongly opposed Galvani's theories on animal electricity. The matter of the scientific controversy betwe en Galvani and Volta is examined here in the light of two centuries of electrophysiological studies leading to the modern understanding of e lectrical excitability in nerve and muscle. By surveying the work of s cientists such as Nobili, Matteucci, du Bois-Reymond, von Helmholtz, B ernstein, Hermann, Lucas, Adrian, Hodgkin, Huxley, and Katz, the real matter of the debate raised by Galvani's discoveries is here reconside red. In addition, a revolutionary phase of the 18th century science th at opened the way for the development of modern neurosciences is reeva luated. (C) 1998 Elsevier Science Inc.