TROGLITAZONE REDUCES PLASMA LEPTIN CONCENTRATION BUT INCREASES HUNGERIN NIDDM PATIENTS

OBJECTIVE - Troglitazone, which improves peripheral insulin resistance of experimental diabetic animals and diabetic patients, affects ob ge ne expression in the adipose tissue of rodents. The present study was undertaken to examine a hypothesis that clinical administration of tro glitazone may reduce circulating leptin levels and affect eating behav ior in NIDDM patients. RESEARCH DESIGN AND METHODS - Troglitazone was administered at a dosage of 200 mg twice daily for 12 weeks in 20 poor ly controlled NIDDM patients. Chronological changes in glycemic contro l, serum lipids, immunoreactive leptin (IRL) levels, and BMI were meas ured. Body fat weight was also assessed by bioelectric impedance. RESU LTS - Troglitazone significantly decreased fasting plasma glucose, ser um immunoreactive insulin, and HbA(1c) levels. Serum levels of IRL and triglyceride were significantly reduced by troglitazone administered for 4, 8, and 12 weeks. Troglitazone administration significantly incr eased the BMI in NIDDM patients, and two-thirds of the patients compla ined of increased hunger after the start of troglitazone administratio n. CONCLUSIONS - Troglitazone significantly reduces circulating leptin levels at clinical doses. It may affect the eating behavior of poorly controlled NIDDM patients through the improvement of glycemic control and/or the reduction of circulating leptin.