HYPERGLYCEMIA IS A FACTOR FOR AN INCREASE IN SERUM CERULOPLASMIN IN TYPE-2 DIABETES

OBJECTIVE - To examine if there is a correlation between high blood gl ucose and serum ceruloplasmin (Cp) levels. RESEARCH DESIGN AND METHODS - Serum Cp levels were measured in 637 patients with type 2 diabetes (all type 2 diabetes group). For the follow-up type 2 diabetes group, 161 patients who had not had any changes in their situation during the last year that are known to influence serum Cp levels were reexamined 1 year later. The control group was composed of 158 healthy individua ls. Serum Cp and blood HbA(1c) levels were measured by radial immunodi ffusion and high-performance liquid chromatography assays, respectivel y. RESULTS - Serum Cp levels in the all type 2 diabetes group were sig nificantly higher than those in the control group (P < 0.0001), althou gh the serum Cp levels did not correlate with the blood HbA(1c) levels in the all type 2 diabetes group (r = 0.055, P = 0.351). Then we eval uated those factors (Delta-log Cp and h-HbA(1c)) in the follow-up type 2 diabetes group to minimize changes from the genetic differences and to exclude any known factors influencing serum Cp levels. This indica ted that the Delta-HbA(1c) had a positive correlation to the Delta-log Cp (r = 0.304, P < 0.0001). CONCLUSIONS - A persistent high blood glu cose (namely HbA(1c)) is associated with an increase in serum Cp level s over 1 year.