A NEW STRATEGY FOR THE SYNTHESIS OF CINNOLINE DERIVATIVES

Authors
SCOBIE M TENNANT G
Citation
M. Scobie et G. Tennant, A NEW STRATEGY FOR THE SYNTHESIS OF CINNOLINE DERIVATIVES, Journal of the Chemical Society, Chemical Communications, (23), 1993, pp. 1756-1757
Citations number
7
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
23
Year of publication
1993
Pages
1756 - 1757
Database
ISI
SICI code
0022-4936(1993):23<1756:ANSFTS>2.0.ZU;2-#
Abstract
Readily accessible 3-amino-5-hydroxy-4-(2-nitroaryl)pyrazoles undergo efficient base-catalysed cyclisation to afford 7-substituted 1-hydroxy -3H-pyrazolo[3,4-c]cinnoline 5-N-oxides, hypochlorite oxidation of whi ch provides a viable synthetic route to hitherto inaccessible cinnolin e-4-carboxylic acid 1-N-oxides.