A NEW-TYPE OF SAFETY-CATCH LINKER CLEAVED BY INTRAMOLECULAR ACTIVATION OF AN AMIDE ANCHORAGE AND ALLOWING AQUEOUS PROCESSING IN SOLID-PHASEPEPTIDE-SYNTHESIS

Authors
SOLA R SAGUER P DAVID ML PASCAL R
Citation
R. Sola et al., A NEW-TYPE OF SAFETY-CATCH LINKER CLEAVED BY INTRAMOLECULAR ACTIVATION OF AN AMIDE ANCHORAGE AND ALLOWING AQUEOUS PROCESSING IN SOLID-PHASEPEPTIDE-SYNTHESIS, Journal of the Chemical Society, Chemical Communications, (23), 1993, pp. 1786-1788
Citations number
12
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
23
Year of publication
1993
Pages
1786 - 1788
Database
ISI
SICI code
0022-4936(1993):23<1786:ANOSLC>2.0.ZU;2-B
Abstract
The N3-phenyloxycarbonyl-L-2,3-diaminopropionic acid residue behaves a s a versatile linker [Dpr(Phoc)linker] displaying high stability under neutral and acidic conditions but under goes activation under mild al kaline conditions for the release of peptide acids or amides by nucleo philic cleavage.