SYNTHESIS AND ANALGESIC ACTIVITY OF NICOTINIC ESTERS OF MORPHINE DERIVATIVES

Authors
HOSZTAFI S KOHEGYI I SIMON C FURST Z
Citation
S. Hosztafi et al., SYNTHESIS AND ANALGESIC ACTIVITY OF NICOTINIC ESTERS OF MORPHINE DERIVATIVES, Arzneimittel-Forschung, 43-2(11), 1993, pp. 1200-1203
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
43-2
Issue
11
Year of publication
1993
Pages
1200 - 1203
Database
ISI
SICI code
0004-4172(1993)43-2:11<1200:SAAAON>2.0.ZU;2-E
Abstract
The synthesis of morphine nicotinates is described using nicotinyl chl oride in the presence of pyridine. Isomorphine and isocodeine nicotina tes were prepared from the corresponding morphine and codeine derivati ves with nicotinic acid in the presence of triphenylphosphine and diet hyl azodicarboxylate. Unexpectedly the reaction of 14-hydroxy-dihydrom orphinone derivatives was anomalous, enolesters were formed. The analg etic activity of selected compounds was determined.