A NEW PROTOCOL FOR THE SYNTHESES OF (E)-3-BENZYLIDENECHROMAN-4-ONES -A SIMPLE SYNTHESIS OF THE METHYL-ETHER OF BONDUCELLIN

Development of a simple new methodology for the synthesis of (E)-3-ben zylidenechroman-4-ones using methyl 3-aryl-3-hydroxy-2-methylenepropan oates, the Baylis-Hillman adducts derived from methyl acrylate, and th e application of this methodology for the synthesis of the methyl ethe r of bonducellin, an important natural product, and 3-(4-methoxybenzyl idene)-6-methoxychroman-4-one an antifungal agent, are described.