REGIOSELECTIVE DIRECTED LITHIATION OF N-BOC 3-HYDROXYPYRROLIDINE - SYNTHESIS OF 2-SUBSTITUTED 4-HYDROXYPYRROLIDINES

Authors
SUNOSE M PEAKMAN TM CHARMANT JPH GALLAGHER T MACDONALD SJF
Citation
M. Sunose et al., REGIOSELECTIVE DIRECTED LITHIATION OF N-BOC 3-HYDROXYPYRROLIDINE - SYNTHESIS OF 2-SUBSTITUTED 4-HYDROXYPYRROLIDINES, Chemical communications, (16), 1998, pp. 1723-1724
Citations number
17
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
16
Year of publication
1998
Pages
1723 - 1724
Database
ISI
SICI code
1359-7345(1998):16<1723:RDLON3>2.0.ZU;2-N
Abstract
N-Boc 3-hydroxypyrrolidine 1 undergoes directed C-lithiation at C5 and not, as previously reported, at C2; the resulting dilithiated interme diate 6 has been trapped by a range of electrophiles to give 2-substit uted 4-hydroxypyrrolidines 7.