CEREBRAL EXCITATORY AMINO-ACIDS AND NA-ATPASE ACTIVITY DURING RESUSCITATION OF SEVERELY HYPOXIC NEWBORN PIGLETS(,K+)

We tested the hypothesis that early brain recovery in hypoxic newborn piglets is improved by resuscitating with an O-2 Supply close to the m inimum level required by the newborn piglet brain. Severely hypoxic 2- 5-d-old anaesthetized piglets were randomly divided into three resusci tation groups: hypoxaemic (n = 8), 21% O-2 (n = 8), and 100% O-2 group s (n = 8). The hypoxaemic group was mechanically ventilated with 12-18 % O-2 adjusted to achieve a cerebral venous O-2 Saturation of 17-23% ( baseline; 45 +/- 1%, mean +/- SEM). During the 2 h resuscitation perio d, extracellular aspartate and glutamate concentrations in the cerebra l striatum were higher during hypoxaemic resuscitation (p = 0.044 and p = 0.055, respectively) than during resuscitation with 21% O-2 or 100 % O-2, suggesting an unfavourable accumulation of potent excitotoxins during hypoxaemic resuscitation. The cell membrane Na+, K+-ATPase acti vity of cerebral cortical tissue after 2 h resuscitation was similar i n the three groups (p = 0.30). In conclusion, hypoxaemic resuscitation did not normalize early cerebral metabolic recovery as efficiently as resuscitation with 21% O-2 or 100% O-2. Resuscitation with 21% O-2 wa s as efficient as resuscitation with 100% O-2 in this newborn piglet h ypoxia model.