NEPHROPATHY AND HYPERTENSION AS MANIFESTATIONS IN A 13-Y-OLD GIRL WITH PRIMARY ANTIPHOSPHOLIPID SYNDROME

Severe renal hypertension due to both unilateral renal arterial occlus ion and renal thrombotic microangiopathy developed in a 13-y-old girl as a manifestation of primary antiphospholipid antibody syndrome. The combination of the intravenous high-dose urokinase therapy and oral an ticoagulation therapy, comprising aspirin, warfarin and dipyridamole, was significantly effective in improving her renal function and preven ting thrombotic events during an 18-month follow-up period.