MICROSENSOR-AIDED MEASUREMENTS MEASUREMENTS OF CELLULAR SIGNALING ANDMETABOLISM ON TUMOR-CELLS - THE CELL MONITORING-SYSTEM (CMS(R))

Microsensors provide instruments particularly suited for the rapid, no ninvasive and on-line analysis of cell and tissue cultures. The micros ensor system presented in this paper is a modular arrangement of vario us planar and nonplanar sensor elements for the measurement of physiol ogical parameters of cell cultures. An optic access to the cultures (e .g. for light microscopy and spectrophotometric techniques) is also pr ovided for a parallel and comparative data acquisition. The system was originally designed for biomedical research in chemotherapy (predicat ive chemotherapy assays) and pharmacology but it turned out to be also an effective tool for toxicological and environmental research.