SYNTHESIS AND ANTILEISHMANIAL ACTIVITY OF SOME CHROMON-8-YLALKANOIC ACIDS AND THEIR METHYL-ESTERS

Authors
BHATTI SP GARG CP KAPOOR RP KAPIL A SHARMA S
Citation
Sp. Bhatti et al., SYNTHESIS AND ANTILEISHMANIAL ACTIVITY OF SOME CHROMON-8-YLALKANOIC ACIDS AND THEIR METHYL-ESTERS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 37(6), 1998, pp. 553-557
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
37
Issue
6
Year of publication
1998
Pages
553 - 557
Database
ISI
SICI code
0376-4699(1998)37:6<553:SAAAOS>2.0.ZU;2-Z
Abstract
Some new 2-(2-aryl-6-methylchromon-8-yl)alkanoic acids 7 and their met hyl esters 6 have been synthesized from appropriate 8-alkanoylflavones 5 by 1,2-aryl migration of flavone ring using iodobenzene diacetate ( IBD). Some of the compounds have been assayed for their in vitro antil eishmanial activity on Leishmania donovam strain UR-6. Compound 7c has been found to possess promising activity.