BETA-LACTAM ANTIBIOTICS, BETA-LACTAMASES AND BACTERIAL-RESISTANCE

Authors
KOTRA LP MOBASHERY S
Citation
Lp. Kotra et S. Mobashery, BETA-LACTAM ANTIBIOTICS, BETA-LACTAMASES AND BACTERIAL-RESISTANCE, Bulletin de l'Institut Pasteur, 96(3), 1998, pp. 139-150
Citations number
61
Categorie Soggetti
Virology,Microbiology,Immunology
Journal title
Bulletin de l'Institut Pasteur → ACNP
ISSN journal
00202452
Volume
96
Issue
3
Year of publication
1998
Pages
139 - 150
Database
ISI
SICI code
0020-2452(1998)96:3<139:BABAB>2.0.ZU;2-H
Abstract
beta-Lactams are the most prescribed antibacterials for the treatment of bacterial infections. Bacteria have developed mechanisms to resist the action of beta-lactam drugs, of which the catalytic function of be ta-lactamase is the most important, These enzymes catalyse hydrolysis of beta-lactam antibiotics, whereby the drug is destroyed. This review offers a perspective on the function of these enzymes and their clini cal implications.