Rd. Wagner et E. Balish, POTENTIAL HAZARDS OF PROBIOTIC BACTERIA FOR IMMUNODEFICIENT PATIENTS, Bulletin de l'Institut Pasteur, 96(3), 1998, pp. 165-170
Probiotic bacteria provide a variety of health benefits to immunocompe
tent hosts; however, their use in immunodeficient patients may pose pr
oblems. Some probiotics are closely related to bacteria that are oppor
tunistic pathogens and can transfer antibiotic resistance genes. Intes
tinal bacteria have recently been associated with inflammatory and aut
oimmune diseases in immunodeficient hosts; similar problems may arise
if probiotics are fed to immunodeficient patients. The safety, efficac
y, benefits and costs of feeding probiotic bacteria to immunodeficient
patients needs to be carefully considered and fully researched to ass
ure they will not cause infectious, inflammatory or autoimmune disease
s in these susceptible hosts.